Disease Severity and Effective Parasite Multiplication Rate in Falciparum Malaria
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چکیده
منابع مشابه
Disease Severity and Effective Parasite Multiplication Rate in Falciparum Malaria
Patients presenting with severe falciparum malaria in a Bangladeshi tertiary hospital had higher total parasite burden, estimated by parasitemia and plasma PfHRP2, than uncomplicated malaria patients despite shorter fever duration. This suggests that higher parasite multiplication rates (PMR) contribute to causing the higher biomass found in severe disease. Compared with patients without a hist...
متن کاملSir2a regulates rDNA transcription and multiplication rate in the human malaria parasite Plasmodium falciparum
The Plasmodium falciparum histone deacetylase Sir2a localizes at telomeric regions where it contributes to epigenetic silencing of clonally variant virulence genes. Apart from telomeres, PfSir2a also accumulates in the nucleolus, which harbours the developmentally regulated ribosomal RNA genes. Here we investigate the nucleolar function of PfSir2a and demonstrate that PfSir2a fine-tunes ribosom...
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In malaria-endemic areas, Plasmodium falciparum parasitemia is common in apparently healthy children and severe malaria is commonly misdiagnosed in patients with incidental parasitemia. We assessed whether the plasma Plasmodium falciparum DNA concentration is a useful datum for distinguishing uncomplicated from severe malaria in African children and Asian adults. P. falciparum DNA concentration...
متن کاملParasite virulence and disease patterns in Plasmodium falciparum malaria.
Heterogeneity in parasite virulence is one of several factors that have been proposed to contribute to the wide spectrum of disease severity in Plasmodium falciparum malaria. We used observed age-structured patterns of disease to define a population structure of P. falciparum, where the latter contains several independently transmitted antigenic types or "strains" that each induce some degree o...
متن کاملInfluence of host factors and parasite biomass on the severity of imported Plasmodium falciparum malaria
OBJECTIVES Imported malaria in France is characterized by various clinical manifestations observed in a heterogeneous population of patients such as travelers/expatriates and African migrants. In this population, host factors and parasite biomass associated with severe imported malaria are poorly known. METHODS From data collected by the Centre National de Référence du Paludisme, we identifie...
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ژورنال
عنوان ژورنال: Open Forum Infectious Diseases
سال: 2017
ISSN: 2328-8957
DOI: 10.1093/ofid/ofx169